ABSTRACT
The cytotoxic activity of Iso(thio)cyanate derivatives and some new organophosphorus compounds were determined,using MTT assay against human hepatocellular carcinoma (HepG2) and adenocarcinoma breast (MCF-7) incomparison with the reference drug 5-flurouracil. All the selected products have been tested and showed concentrationdependent increase in the growth inhibition percentage against HepG2 and MCF-7. Where, the thietane derivativesrevealed anticancer activity with IC50 (20, 8.9 µg/ml) against HepG2 and (20, 10.3 µg/ml) against MCF-7; while,thiazinane compounds showed IC50 (12.7, 32.5 µg/ml) against HepG2 and (20 and 20 µg/ml) against MCF7. The newly synthesized azetidines showed anticancer activity with IC50 (13.5 and 32.5 µg/ml) against HepG2and IC50 (10 and 25.9 µg/ml) against MCF-7 cancer. Moreover, azetidinedione compound exhibited more potentactivity than the azetidinone with both types of cancer cell lines. In addition, the cytotoxic activity of the iso(thio)cyanates, and malonamic acid methyl ester compound were also investigated. 4-Methoxyphenyl isothiocyanate andmethylisothiocyanate, with IC50 (25.9, 12.3 and 40, 20 µg/ml), respectively, against HepG2 and MCF-7 cancer cells.1, 2-Dichloro-4-isocyanato-benzene was similar in potency to the known anticancer drug 5-flurouracil with IC50 (5.3µg/ml) versus 5 µg/ml for 5-flurouracil against MCF-7. While, malonamic acid methyl ester compound had no effecton both types of cancer cell lines.